SeraSeal on Arterial Bleeding

Do not be confused by the similar language between venous bleeding and arterial bleeding in much of the discussion about applying SeraSeal® . There are significant departures in technique.

SeraSeal® is a new technical product for professional use. Physicians have been taught to deal with bleeding in traditional ways.  SeraSeal® is not traditional. It introduces new ways of controlling bleeding.

Simply apply drops of liquid from the SeraSeal® from the injectable vial with a tuberculin syringe, with or without the needle, an eye dropper, pipette or even a fiber optic-guided catheter at the source of bleeding.

RECOGNIZING THE CLOTTING EVENT is easy – and very important. The clot actually takes place when you see the blood color change to bright red. This is the indicator that you should stop applying SeraSeal. Any SeraSeal® applied after the color changes to bright red is wasted.

OBSERVING AND TREATING THE SOURCE OF BLEEDING is very important. The correct technique for stopping arterial bleeding is fast droplets topically applied from the superior edge of the artery – at least one per second – until you observe the blood color change to bright red. This forms a concentric cascading clot that reliably seals the artery.

NOTE: NEVER inject SeraSeal® into the vascular system. Injecting SeraSeal could precipitate dissimulated intravascular coagulation (DIC).

LEAVE IT ALONE! Clots formed with SeraSeal® are like ordinary blood clots, except, as the name suggests, they form much faster. Minutes are reduced to seconds. But lapse of time remains important for the fibrinogen strands to crosslink and tighten. With SeraSeal®, this process just takes about 60 seconds, and strengthens with additional time.

Resisting the temptation to touch the clot remains the single most difficult non-action for traditionally-trained physicians. Even with a Wortham Laboratories representative in surgery with them – urging them to leave the clot untouched for at least 60 seconds – many physicians instinctively continue to dab at the clot. Dabbing invariably dislodges the clot and restarts the bleeding, which requires re-application of SeraSeal®. Without exception, any dissatisfaction with SeraSeal®’s performance can be traced back to this failure to leave the clot undisturbed for at least 60 seconds.

When you are doing a procedure, 60 seconds is a long time to stand around waiting for a clot to form. So we recommend A LEAPFROG TECHNIQUE. When you have applied SeraSeal® and identified the blood color shift to bright red, move on to another part of the procedure. After 60 seconds or more, come back to the SeraSeal® site and inspect it for untreated bleeding. This reduces the temptation to dab at the clot while fibrinogen strands crosslink, and your procedure is not delayed while waiting for the clot to strengthen. Once you have confirmed that all bleeding has been arrested, you can then confidently resume the other parts of the procedure.