How SeraSeal® Works

The initiation of the hemostatic sealing properties of SeraSeal® begins with the release of tissue thromboplastin from the creation of a wound. This triggering device causes a series of complex reactions to occur. Initially, the ions of platelet phospholipids and cations from amine groups in fibrinogen/fibrin monomers and tissue proteins, cross-link with the agar in SeraSeal®, creating an α-1,6-linked galactophospho and α-1,6-galactoamine forming an agar barrier over the wound. This barrier reduces blood from escaping through the opening of the wound, allowing the patient´s clotting cascade system to form a fibrin clot sooner.

There are two distinct pathways for fibrin clot formation: the extrinsic and intrinsic pathways. The vitamin K factors in SeraSeal® support both clotting pathways to form a fibrin clot in seconds instead of minutes. The fibrin clot adheres to the initial agar barrier, reinforcing the physical sealant.

SeraSeal® Clotting Cascade


Platelets + galactopyranose complex sugar (agar) Polymerization thin transparent barrier.

Platelet Phospholipid ions and cations from amine groups in fibrinogen/fibrin monomers and tissue proteins adhere to the polymerized complex sugar, forming a barrier over the wound.

* SeraSeal® support points in the clotting cascade system.


  SeraSeal® utilizes both the intrinsic and extrinsic pathways to support the promotion of clot formation in seconds, even in the presence of coagulopathies.
Characteristics of SeraSeal®
  SeraSeal® Fibrin Glues






SeraSeal® is a primary one component system containing agar, bovine proteins, stabilizers, an antiseptic agent. SeraSeal is fibrinogen and collagen free.



Fibrin Glues are an adjunct two component system containing human fibrinogen or bovine collagen in one chamber, and thrombin or a polyol in another chamber.






SeraSeal® creates an agar physical barrier over the wound and reinforced with a fibrin clot.



Fibrin Glues utilizes the cross-linking of two components to form a patch over the bleeding site; thereby, impeding blood flow and passively allowing the patient’s blood to clot to seal the wound.



Clotting times



SeraSeal® achieves hemostasis in 2-3 seconds for most bleeds, and < 10 seconds for large arterial bleeds.



Fibrin Glues typically clot venous bleeds in 1-3 minutes, and 5-10 minutes for small arterial hemorrhages.






SeraSeal® effective in a wide range of coagulopathies without significantly increasing clotting times.



Fibrin Glues require preparation before use and cannot be used in all surgical procedures.






SeraSeal® can arrest any type of hemorrhage in any part of the body.  No preparation, no mixing, ready to use.



Fibrin Glues are used on venous bleeds, and only small arterial blood vessels.






Multiple delivery systems for different levels of hemorrhage.  Can be used in emergency and trauma procedures. Fibrin Glues limited to mild to moderate forms of hemorrhage.